Arendt D, Nübler-Jung K
Biologisches Institut I (Zoologie) der Albert-Ludwigs-Universität Freiburg, Germany.
Bioessays. 1996 Mar;18(3):255-9. doi: 10.1002/bies.950180314.
Comparing expression patterns of orthologous genes between insects and vertebrates, we have recently proposed that the ventral nerve cord in insects may correspond to the dorsal nerve cord in vertebrates. Here we show that the early development of the insect and vertebrate brain anlagen is indeed very similar. Insect and vertebrate brains express similar sets of genes in comparable areas with similar functions in the adult. In addition, early axogenesis establishes surprisingly similar patterns of axonal connectivity in both groups. We therefore propose that insect and vertebrate brains are built according to a common ground plan, and that specific areas of the insect and vertebrate brains be considered as homologous, meaning that these areas already existed, with their specific functions, in their common ancestor.
通过比较昆虫和脊椎动物直系同源基因的表达模式，我们最近提出昆虫的腹神经索可能与脊椎动物的背神经索相对应。在此我们表明，昆虫和脊椎动物脑原基的早期发育确实非常相似。昆虫和脊椎动物的大脑在成体中具有相似功能的可比区域表达相似的基因集。此外，早期轴突发生在两组中建立了惊人相似的轴突连接模式。因此，我们提出昆虫和脊椎动物的大脑是按照共同的基本蓝图构建的，并且昆虫和脊椎动物大脑的特定区域应被视为同源的，这意味着这些区域在它们的共同祖先中就已经存在，并具有其特定功能。
