Kondo H, Asamura H, Suemasu K, Goya T, Tsuchiya R, Naruke T, Yamagishi K, Uei Y
Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
J Thorac Cardiovasc Surg. 1993 Dec;106(6):1092-7.
Pleural lavage cytology immediately after thoracotomy was performed in 467 patients with lung cancer who had little or no pleural effusion. Forty-two patients (9.0%) had positive results. The positivity of pleural lavage cytology was significantly related to the degree of pleural extension of the tumor, microscopic pleural dissemination, cytologic results of minimal pleural effusion, pathologic stage, presence of lymphatic permeation or vascular invasion, and cell type (adenocarcinoma was predominant). The 3-year survival of the patients having negative and positive results of cytology were 68.7% and 22.9%, respectively. The prognosis of the group with positive results was as poor as that of patients with stage IIIB or IV disease. Pleural lavage cytology is an important prognostic factor that indicates microscopic exfoliation of cancer cells into the pleural cavity, that is, subclinical malignant pleural effusion.
对467例几乎没有或没有胸腔积液的肺癌患者在开胸术后立即进行了胸腔灌洗细胞学检查。42例患者（9.0%）结果呈阳性。胸腔灌洗细胞学检查的阳性结果与肿瘤的胸膜侵犯程度、显微镜下胸膜播散、微量胸腔积液的细胞学结果、病理分期、淋巴管浸润或血管侵犯的存在以及细胞类型（腺癌占主导）显著相关。细胞学检查结果为阴性和阳性的患者3年生存率分别为68.7%和22.9%。阳性结果组的预后与IIIB期或IV期疾病患者的预后一样差。胸腔灌洗细胞学检查是一个重要的预后因素，它表明癌细胞向胸腔的显微镜下脱落，即亚临床恶性胸腔积液。
