Loguercio C, Piscopo P, Guerriero C, De Girolamo V, Disalvo D, Del Vecchio Blanco C
Cattedra di Gastroenterologia, Facolta di Medicina, Potenza, Italy.
Scand J Clin Lab Invest. 1996 Aug;56(5):441-7. doi: 10.3109/00365519609088799.
Glutathione (GSH) is a principal cellular scavenger of free radicals. Chronic alcohol abuse, as well as liver disease, induces a decrease of hepatic GSH. We evaluated the effect of GSH administration (2.4 g day-1 in saline i.v. for 15 days) on the concentration of GSH in plasma and erythrocytes and on liver function tests, including galactose and antipyrine tests. We studied 40 alcoholic cirrhotic patients: 22 treated with GSH (10 persistent alcohol abusers and 12 weaning from alcohol during the study) and 18 treated with saline only (8 persistent alcohol abusers and 10 abstainers). Treatment with GSH improved the concentration of GSH in plasma and erythrocytes only in abstainers from alcohol; it did not affect liver function tests or galactose clearance. Persistent alcohol consumption significantly prolonged antipyrine metabolism; GSH administration counteracted this effect.
谷胱甘肽（GSH）是细胞内主要的自由基清除剂。长期酗酒以及肝脏疾病会导致肝脏中GSH含量降低。我们评估了静脉注射GSH（2.4克/天，溶于生理盐水，持续15天）对血浆和红细胞中GSH浓度以及肝功能测试（包括半乳糖和安替比林测试）的影响。我们研究了40名酒精性肝硬化患者：22名接受GSH治疗（10名持续酗酒者和12名在研究期间戒酒者），18名仅接受生理盐水治疗（8名持续酗酒者和10名戒酒者）。GSH治疗仅在戒酒者中提高了血浆和红细胞中GSH的浓度；它对肝功能测试或半乳糖清除率没有影响。持续饮酒会显著延长安替比林代谢时间；给予GSH可抵消这种影响。
