Hans P, Brichant J F, Franzen A, Faleres X, Lamy M
University Department of Anaesthesia, CHR de la Citadelle, CHU Liège, Belgium.
Acta Anaesthesiol Belg. 1996;47(2):53-8.
We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50% nitrous oxide and 1% enflurane in oxygen. Neuromuscular transmission was monitored by stimulating the ulnar nerve at the wrist and measuring the acceleration of the thumb using the TOF-Guard accelerograph monitor. Supramaximal stimuli of 0.2 ms duration were applied in a single twitch stimulation mode at 1 Hz frequency until completion of block, and in train-of four (TOF) sequence at 2 Hz every 15 sec thereafter. Onset time was longer with atracurium (mean +/- SD:90 +/- 18 sec) than with rocuronium (49 +/- 6 sec). Clinical duration of action (Tl25) was longer with atracurium (52.3 +/- 7.2 min) than with rocuronium (40.0 +/- 6.4 min). Recovery index (Tl25-Tl75) and time for TOF ratio to recover to 0.75 were 17.8 +/- 4.2 and 73.9 +/- 8.8 min with atracurium, and 13.8 +/- 4.1 and 70.4 +/- 14.1 min with rocuronium. The differences between both groups were statistically significant except the difference in the time for TOF to return to 0.75.
我们研究了24例健康成年患者中0.5mg/kg阿曲库铵和0.6mg/kg罗库溴铵的作用时效。采用硫喷妥钠和舒芬太尼诱导麻醉，并用50%氧化亚氮和1%恩氟烷加氧维持麻醉。通过刺激腕部尺神经并使用TOF-Guard加速度仪监测仪测量拇指加速度来监测神经肌肉传递。在1Hz频率下以单次颤搐刺激模式施加持续时间为0.2ms的超强刺激直至阻滞完成，此后每隔15秒以2Hz频率进行四个成串刺激（TOF）。阿曲库铵的起效时间（均值±标准差：90±18秒）比罗库溴铵（49±6秒）长。阿曲库铵的临床作用时间（T125）（52.3±7.2分钟）比罗库溴铵（40.0±6.4分钟）长。阿曲库铵的恢复指数（T125-T175）和TOF比值恢复至0.75的时间分别为17.8±4.2分钟和73.9±8.8分钟，罗库溴铵分别为13.8±4.1分钟和70.4±14.1分钟。除TOF恢复至0.75的时间差异外，两组之间的差异具有统计学意义。
