箔浴补骨脂素加长波紫外线治疗亚急性单纯性痒疹

Foil bath PUVA in the treatment of prurigo simplex subacuta.

作者信息

Streit V, Thiede R, Wiedow O, Christophers E

机构信息

Department of Dermatology, Christian-Albrechts-University, Kiel, Germany.

出版信息

Acta Derm Venereol. 1996 Jul;76(4):319-20. doi: 10.2340/0001555576319320.

DOI:10.2340/0001555576319320

PMID:8869694

Abstract

Prurigo simplex subacuta is a chronic pruritic condition of unknown aetiology. The skin lesions respond to topical corticosteroids, UV-A and UV-B therapy only to a limited degree. Ten patients suffering from prurigo simplex subacuta were treated with foil bath PUVA at a concentration of 0.5 mg 8-methoxypsoralen/l. Using the foil bath method the volume of the psoralen/bath-water solution is restricted to 10 l with the aid of polyethylene foil. The group required a median of 13 (95% CI: 9-19) baths for clearance. The total UV-A dose for the whole group was 19 (95% CI:5-30) J/cm2. Bath PUVA is a safe and well-tolerated therapy in the treatment of prurigo simplex subacuta.

摘要

单纯性亚急性痒疹是一种病因不明的慢性瘙痒性疾病。其皮肤损害对局部皮质类固醇、长波紫外线（UV-A）和中波紫外线（UV-B）治疗仅产生有限的反应。10例单纯性亚急性痒疹患者接受了浓度为0.5mg 8-甲氧基补骨脂素/升的箔浴光化学疗法（PUVA）。使用箔浴法，借助聚乙烯箔将补骨脂素/浴水溶液的体积限制在10升。该组患者清除皮疹中位数需要13次（95%可信区间：9 - 19次）浴疗。整个组的总UV-A剂量为19（95%可信区间：5 - 30）J/cm²。箔浴PUVA是治疗单纯性亚急性痒疹的一种安全且耐受性良好的疗法。