Saulgozis J, Pontaga I, Lowet G, Van der Perre G
Laboratory of Biomechanics of the Latvian Medical Academy, Riga, Latvia.
Physiol Meas. 1996 Aug;17(3):201-11. doi: 10.1088/0967-3334/17/3/006.
Measurement of the velocity of propagation and attenuation of ultrasound (200 kHz) is believed to be a useful non-invasive technique for assessing the mechanical properties of bone. A new method for the determination of ultrasound velocity and attenuation of longitudinal waves in cortical bone was used in vivo and in situ on intact and fractured human tibiae. The measured ultrasound attenuation and velocity were found to be unaffected by the soft tissue between transducers and bone. The ultrasound velocity in vivo on control tibiae was 3614 +/- 32 m s-1 and the attenuation was 5.52 +/- 0.43 dB MHz-1 cm-1. The ultrasound velocity in fractured tibiae was considerably lower 1 week after fracture (2375 +/- 82 m s-1), but had significantly increased after 3 weeks (to 2882 +/- 90 m s-1). A higher attenuation was measured 1 week after fracture (17.81 +/- 3.91 dB MHz-1 cm-1), but it had decreased again 3 weeks after fracture (10.42 +/- 3.56 dB MHz-1 cm-1). In situ studies under well-defined conditions confirmed the in vivo results. The effects of internal plate fixation and gradually cutting through the cortex on the ultrasound velocity and attenuation were studied in situ. These results demonstrate the clinical potential of this technique for the non-invasive assessment of bone fracture healing.
测量超声（200千赫）的传播速度和衰减被认为是评估骨力学性能的一种有用的非侵入性技术。一种用于测定皮质骨中纵波超声速度和衰减的新方法在完整和骨折的人体胫骨上进行了体内和原位研究。发现测得的超声衰减和速度不受换能器与骨之间软组织的影响。对照胫骨的体内超声速度为3614±32米/秒，衰减为5.52±0.43分贝/兆赫·厘米⁻¹。骨折后1周，骨折胫骨的超声速度显著降低（2375±82米/秒），但3周后显著增加（至2882±90米/秒）。骨折后1周测得的衰减较高（17.81±3.91分贝/兆赫·厘米⁻¹），但骨折后3周又再次降低（10.42±3.56分贝/兆赫·厘米⁻¹）。在明确条件下的原位研究证实了体内研究结果。在原位研究了内固定钢板和逐渐切开皮质对超声速度和衰减的影响。这些结果证明了该技术在无创评估骨折愈合方面的临床潜力。
