Kawaguchi M, Fujii T, Kamiya Y, Ito J, Okada M, Sakuma N, Fujinami T
Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
Acta Diabetol. 1996 Jul;33(2):100-2. doi: 10.1007/BF00569417.
To investigate the effect of fructose ingestion on sorbitol and fructose 3-phosphate (F3P) in erythrocytes, we administered 50 g fructose with and without treatment with an aldose reductase inhibitor, epalrestat, to seven healthy, normal-glucose-tolerant, male volunteers aged 20-43 years. The same subjects were given 50 g glucose on another day. The sorbitol and F3P contents in their erythrocytes increased significantly, reaching peak levels at 60 min and 180 min, respectively, following fructose in gestion. On the other hand, glucose ingestion did not cause any statistically significant change in sorbitol content in their erythrocytes, although it significantly elevated their F3P content. Treatment with epalrestat had no significant effect on incremental changes in erythrocyte sorbitol and F3P content following fructose ingestion. This suggests that oral fructose may be converted directly to sorbitol and F3P in erythrocytes instead of being converted via glucose. Thus, the dietary intake of fructose may affect the concentrations of sorbitol and F3P in erythrocytes in normal men.
为研究摄入果糖对红细胞中山梨醇和果糖-3-磷酸（F3P）的影响，我们对7名年龄在20 - 43岁、健康、糖耐量正常的男性志愿者给予50克果糖，并分别在使用和不使用醛糖还原酶抑制剂依帕司他的情况下进行观察。在另一天，让相同的受试者摄入50克葡萄糖。摄入果糖后，他们红细胞中的山梨醇和F3P含量显著增加，分别在60分钟和180分钟达到峰值。另一方面，摄入葡萄糖虽使其红细胞中的F3P含量显著升高，但未导致其红细胞中山梨醇含量发生任何具有统计学意义的变化。依帕司他治疗对摄入果糖后红细胞中山梨醇和F3P含量的增量变化无显著影响。这表明口服果糖可能在红细胞中直接转化为山梨醇和F3P，而非通过葡萄糖转化。因此，正常男性的果糖饮食摄入量可能会影响红细胞中山梨醇和F3P的浓度。
