Yokozawa T, Chung H Y, Dong E, Oura H
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Exp Toxicol Pathol. 1995 Nov;47(5):341-4. doi: 10.1016/S0940-2993(11)80344-1.
Male LWH: Wistar rats were given creatinine (Cr) intraperitoneally at a dose of 1.00 g/kg body weight, and the urine was collected for 3 h after administration. Magnesium lithospermate B, a compound newly isolated from Salviae Miltiorrhizae Radix, was administered intraperitoneally 30 min before and 30 min after Cr administration. The excretion of urinary creatol and methylguanidine induced by Cr decreased in a dose-dependent manner. Since we have already shown that the main contributor to the Cr-->creatol oxidation step is the hydroxyl radical, magnesium lithospermate B may act as a radical scavenger.
给Wistar大鼠腹腔注射肌酐（Cr），剂量为1.00 g/kg体重，并在给药后收集3小时尿液。在注射Cr前30分钟和注射Cr后30分钟腹腔注射从丹参中新分离出的化合物丹酚酸B镁。Cr诱导的尿肌醇和甲基胍排泄呈剂量依赖性降低。由于我们已经表明Cr→肌醇氧化步骤的主要促成因素是羟基自由基，因此丹酚酸B镁可能作为自由基清除剂发挥作用。
