Ripoll E, Revilla M, Hernández E R, Arribas I, Villa L F, Rico H
Central Laboratory of the Príncipe de Asturias University Hospital, Madrid, Spain.
Eur J Clin Invest. 1996 Aug;26(8):681-5. doi: 10.1111/j.1365-2362.1996.tb02153.x.
Having observed that serum beta(2)-microglobulin concentration correlates with serum tartrate-resistant acid phosphatase (TRAP) concentration in postmenopausal osteoporosis, and that metacarpal endosteal diameter is dependent on bone resorption, we correlated the two biochemical parameters with the radiographic parameter to determine if beta(2)-microglobulin behaves like a biological marker of bone remodelling. In 105 women (mean age 68 +/- 4 years) consisting of 60 normal postmenopausal women and 55 osteoporotic postmenopausal women, there was a significant positive correlation between metacarpal endosteal diameter and these two biochemical values (r = 0.66 with beta(2)-microglobulin and r = 0.68 with TRAP in the osteoporotic postmenopausal women; r = 0.48 with beta(2)-microglobulin and r = 0.56 with TRAP in the normal postmenopausal women; P < 0.001 for all comparisons). All three measurements were significantly higher (P < 0.001) in the osteoporotic postmenopausal women than in the normal postmenopausal women. These findings show that serum beta(2)-microglobulin behaves like a biological marker of remodelling.
鉴于已观察到绝经后骨质疏松症患者血清β2-微球蛋白浓度与血清抗酒石酸酸性磷酸酶（TRAP）浓度相关，且掌骨骨内膜直径取决于骨吸收，我们将这两个生化参数与影像学参数进行关联，以确定β2-微球蛋白是否表现为骨重塑的生物学标志物。在105名女性（平均年龄68±4岁）中，包括60名绝经后正常女性和55名绝经后骨质疏松女性，掌骨骨内膜直径与这两个生化值之间存在显著正相关（在绝经后骨质疏松女性中，与β2-微球蛋白的r = 0.66，与TRAP的r = 0.68；在绝经后正常女性中，与β2-微球蛋白的r = 0.48，与TRAP的r = 0.56；所有比较的P < 0.001）。绝经后骨质疏松女性的所有三项测量值均显著高于绝经后正常女性（P < 0.001）。这些发现表明血清β2-微球蛋白表现为重塑的生物学标志物。
