Bar J, Friedman S, Erman A, Kaplan B, Hod M, Boner G, Ovadia J
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah Tiqvu, Israel.
J Hum Hypertens. 1996 Sep;10 Suppl 3:S111-4.
The value of microalbuminuria in predicting hypertensive complications in pregnant patients at high risk was tested in a prospective trial. A total of 276 patients were studied (142 in the study group vs 134 controls). Albumin was measured in 8-h overnight urine collection throughout pregnancy using radioimmunoassay technique. The pregnant women, in both the study and control groups demonstrated a statistically significant increase in albumin excretion rate in the second and third trimester compared with the first. Using logistic and linear regression models, the presence of microalbuminuria in the early third trimester was proven to be predictive of severe disease (odds ratio 2.1, confidence interval (CI) 1.26-3.53) and birth weight (R2 = 0.7, P < 0.05) in the study group. Intrauterine growth retardation and neonatal outcome were less predictable. With the introduction of radioimmunoassays, we believe severe disease can be predicted by detecting microalbuminuria in the early third trimester of pregnancy in high risk patients.
在一项前瞻性试验中，对微量白蛋白尿在预测高危孕妇高血压并发症中的价值进行了测试。共研究了276例患者（研究组142例，对照组134例）。在整个孕期，使用放射免疫分析技术对8小时夜间尿液收集样本中的白蛋白进行测量。研究组和对照组的孕妇在妊娠中期和晚期的白蛋白排泄率相比妊娠早期均有统计学意义的显著增加。使用逻辑回归和线性回归模型，结果证明在妊娠晚期早期存在微量白蛋白尿可预测研究组中的严重疾病（优势比2.1，置信区间（CI）1.26 - 3.53）和出生体重（R2 = 0.7，P < 0.05）。宫内生长迟缓及新生儿结局较难预测。随着放射免疫分析的引入，我们认为通过检测高危患者妊娠晚期早期的微量白蛋白尿可以预测严重疾病。
