Lahad A, Heckbert S R, Patrick D L, Psaty B M
Department of Health Services, University of Washington, Seattle, USA.
J Hum Hypertens. 1996 Sep;10 Suppl 3:S115-21.
In order to determine whether a hostile attitude is associated with hypertension in post-menopausal women, we conducted a cross-sectional study of a sample of post-menopausal women enrollees from the Group Health Cooperative (Seattle, Washington). Out-patient medical records were reviewed for all subjects. Hypertension was defined as a recorded diagnosis of hypertension and treatment with an anti-hypertensive drug. Borderline hypertensives were excluded. Women were interviewed by telephone and asked the 14 questions comprising the Hostile-Affect (HOS) and Aggressive-Responding (AGGR) factors of the Cook-Medley hostility scale. Scores were grouped into high vs low HOS and AGGR. The AGGR score was available for 430 hypertensives and 628 normotensives. The HOS score was available for 436 hypertensives and 616 normotensives. High AGGR scores had a borderline association with hypertension (Odds Ratio (OR) = 1.26; 95% Confidence interval (CI) = 0.97-1.62). HOS was not associated with hypertension. Adjusting for age, physical activity, diabetes mellitus, cholesterol level, tobacco and alcohol use, weight and race, changed the association of AGGR with hypertension only slightly (OR = 1.22; CI = 0.92-1.63). We found a weak association between the prevalence of treated hypertension and AGGR in post-menopausal women. There was no association between the HOS component and hypertension. The results of this study support the need for prospective studies of the role of psychological factors in the development of hypertension in post-menopausal women. If this association is confirmed, AGGR measures may help identify women at high-risk who are most likely to benefit from hypertension screening and primary prevention.
为了确定敌意态度是否与绝经后女性的高血压相关，我们对来自Group Health Cooperative（华盛顿州西雅图）的绝经后女性参保者样本进行了一项横断面研究。查阅了所有研究对象的门诊病历。高血压定义为有高血压的记录诊断并接受抗高血压药物治疗。临界高血压患者被排除。通过电话对女性进行访谈，并询问了构成Cook-Medley敌意量表中敌意情感（HOS）和攻击反应（AGGR）因子的14个问题。分数被分为高HOS和低HOS以及高AGGR和低AGGR。430名高血压患者和628名血压正常者有AGGR分数。436名高血压患者和616名血压正常者有HOS分数。高AGGR分数与高血压有边缘相关性（优势比（OR）=1.26；95%置信区间（CI）=0.97-1.62）。HOS与高血压无关。在调整年龄、身体活动、糖尿病、胆固醇水平、烟酒使用、体重和种族后，AGGR与高血压的关联仅略有变化（OR = 1.22；CI = 0.92-1.63）。我们发现绝经后女性中接受治疗的高血压患病率与AGGR之间存在弱关联。HOS成分与高血压之间无关联。本研究结果支持对心理因素在绝经后女性高血压发生中的作用进行前瞻性研究的必要性。如果这种关联得到证实，AGGR测量可能有助于识别最有可能从高血压筛查和一级预防中获益的高危女性。
