Lahad A, Heckbert S R, Koepsell T D, Psaty B M, Patrick D L
Department of Health Services, University of Washington, Seattle, USA.
J Psychosom Res. 1997 Aug;43(2):183-95. doi: 10.1016/s0022-3999(96)00369-8.
Hostility can predict coronary heart disease (CHD) and total mortality in men. However, in women this association has not been as thoroughly explored. This study examines whether hostile and aggressive attitudes are associated with myocardial infarction (MI) in postmenopausal women. Cases included 277 women who presented with an incident MI. Controls included a random sample of 988 female health maintenance organization enrollees. Women were asked the Hostile-Affect and the Aggressive-Responding factors of the Cook-Medley Hostility Scale. The Hostile-Affect score was linearly associated with increased risk for MI (odds ratio [OR] per point = 1.22; 95% confidence interval [CI95%] = 1.07-1.38), whereas the Aggressive-Responding score had a modest protective effect (OR = 0.92 per point; CI95% = 0.84-1.02); p = 0.009. Adjustment for sociodemographic and MI risk factors altered these results only slightly. These hostility measures are easily administered, and could help to identify women who are at high risk for CHD and who may benefit from preventive measures.
敌意能够预测男性的冠心病（CHD）和全因死亡率。然而，在女性中，这种关联尚未得到充分研究。本研究旨在探讨敌意和攻击性态度是否与绝经后女性的心肌梗死（MI）相关。病例包括277名发生急性心肌梗死的女性。对照组包括从988名女性健康维护组织参保者中随机抽取的样本。研究人员询问了女性关于库克-梅德利敌意量表中的敌意情绪和攻击性反应因素。敌意情绪得分与心肌梗死风险增加呈线性相关（每分比值比[OR]=1.22；95%置信区间[CI95%]=1.07-1.38），而攻击性反应得分具有适度的保护作用（每分OR=0.92；CI95%=0.84-1.02）；p=0.009。对社会人口学和心肌梗死风险因素进行调整后，这些结果仅有轻微变化。这些敌意测量方法易于实施，有助于识别冠心病高危女性，她们可能从预防措施中获益。
