Paran E, Anson O, Neumann L
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
J Hum Hypertens. 1996 Sep;10 Suppl 3:S147-52.
To study the effect of diuretics and diuretics discontinuation on the quality of life (QOL) of hypertensive patients.
149 beta blocker treated mild to moderate hypertensive patients were included in the study. Seventy-three were treated by beta blockers (BB's) only and 60 by BB's and diuretics, for 40 patients diuretics was discontinued. Physical symptoms and QOL were assessed before and 9-15 months after the change in treatment.
At baseline, subjects on diuretics experienced more gastrointestinal symptoms, weakness, and sex related problems; and their QOL was poorer. At the end of the follow-up, patients on diuretics scored poorest on physical strength items and on health perceptions; those who were never treated by diuretics scored best; and those who stopped were in between.
Diuretics treatment adversely affect patients' QOL. Cessation of diuretics treatment for at least 9 months improved some aspects of patients' QOL, though those who never received diuretics were better of than others.
研究利尿剂及停用利尿剂对高血压患者生活质量（QOL）的影响。
149例接受β受体阻滞剂治疗的轻至中度高血压患者纳入本研究。其中73例仅接受β受体阻滞剂（BB's）治疗，60例接受BB's和利尿剂治疗，40例停用利尿剂。在治疗改变前及改变后9 - 15个月评估身体症状和生活质量。
基线时，使用利尿剂的受试者出现更多胃肠道症状、虚弱及与性相关的问题；且他们的生活质量较差。随访结束时，使用利尿剂的患者在体力项目和健康认知方面得分最差；从未接受利尿剂治疗的患者得分最佳；停用利尿剂的患者得分介于两者之间。
利尿剂治疗对患者生活质量有不利影响。停用利尿剂治疗至少9个月可改善患者生活质量的某些方面，尽管从未接受利尿剂治疗的患者比其他患者情况更好。
