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啮齿动物细小病毒感染

Rodent parvovirus infections.

作者信息

Jacoby R O, Ball-Goodrich L J, Besselsen D G, McKisic M D, Riley L K, Smith A L

机构信息

Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Lab Anim Sci. 1996 Aug;46(4):370-80.

PMID:8872986
Abstract

Parvoviruses are among the most common infectious agents of laboratory rodents and major impediments to rodent-based research. The original prototypic rodent parvoviruses-minute virus of mice, rat virus, and H-1 virus-have recently been joined by biologically and antigenically distinct parvoviruses in mice, rats, and hamsters. Recognition of the increased diversity of rodent parvoviruses presents new challenges for determining the impact of parvovirus infection on research and for detecting, preventing, and eliminating infection. This review summarizes current knowledge about rodent parvoviruses and parvovirus infections, highlighting recent research on newly isolated virus strains.

摘要

细小病毒是实验用啮齿动物最常见的感染因子之一,也是基于啮齿动物研究的主要障碍。最初的典型啮齿动物细小病毒——小鼠微小病毒、大鼠病毒和H-1病毒——最近又出现了生物学和抗原性不同的细小病毒,分别存在于小鼠、大鼠和仓鼠中。认识到啮齿动物细小病毒多样性的增加,对确定细小病毒感染对研究的影响以及检测、预防和消除感染提出了新的挑战。本综述总结了关于啮齿动物细小病毒和细小病毒感染的现有知识,重点介绍了对新分离病毒株的最新研究。

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