Dudley J P, Cherry J D
Pediatr Res. 1977 Aug;11(8):904-6. doi: 10.1203/00006450-197708000-00010.
The chicken tracheal organ culture system was used to study the effect on cilia function of two frequently used topical decongestants and four mucolytic agents. The agents used were: phenylephrine hydrochloride spray 0.25%, oxymetazoline 0.05%, sodium bicarbonate 7.5%, acetylcysteine 10%, pancreatic dornase 50,000 units/ml, and L-arginine 5.6%. The tracheal rings were given two kinds of exposure to the test drugs. Only pancreatic dornase was not ciliotoxic. Until further data are available, including studies with human organ cultures, it would perhaps be wise to discourage the topical use of phenylephrine hydroxhloride spray 0.25% and oxymetazoline 0.05%, and to consider pancreatic dornase as the mucolytic agent of choice.
鸡气管器官培养系统被用于研究两种常用局部减充血剂和四种黏液溶解剂对纤毛功能的影响。所使用的药物有：0.25%盐酸去氧肾上腺素喷雾剂、0.05%羟甲唑啉、7.5%碳酸氢钠、10%乙酰半胱氨酸、50000单位/毫升胰脱氧核糖核酸酶以及5.6% L-精氨酸。气管环接受了两种方式的受试药物暴露。只有胰脱氧核糖核酸酶没有纤毛毒性。在获得包括人体器官培养研究在内的更多数据之前，或许明智的做法是不鼓励局部使用0.25%盐酸去氧肾上腺素喷雾剂和0.05%羟甲唑啉，并将胰脱氧核糖核酸酶视为首选的黏液溶解剂。
