在酿酒酵母中鉴定出两种类CyP-40亲环蛋白，其中一种是正常生长所必需的。
Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth.
作者信息
Duina A A, Marsh J A, Gaber R F
机构信息
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
出版信息
Yeast. 1996 Aug;12(10):943-52. doi: 10.1002/(sici)1097-0061(199608)12:10<943::aid-yea997>3.0.co;2-3.
We report the analysis of two Saccharomyces cerevisiae cyclophilins, Cpr6 and Cpr7, identified by their ability to interact in vivo with the transcriptional regulator Rpd3. Both cyclophilins have an extended carboxy-terminal region containing a three-unit tetratricopeptide repeat (TPR) motif and share significant amino acid identity with the mammalian cyclophilin CyP-40. Neither CPR6 nor CPR7 is essential but deletion of CPR7 results in a significant impairment of the rate of cell division. This is the first demonstration that a member of the cyclophilin family is required for normal cell growth.
我们报告了对两种酿酒酵母亲环蛋白Cpr6和Cpr7的分析，它们是通过在体内与转录调节因子Rpd3相互作用的能力而被鉴定出来的。这两种亲环蛋白都有一个延伸的羧基末端区域，其中包含一个由三个单元组成的四肽重复（TPR）基序，并且与哺乳动物亲环蛋白CyP-40有显著的氨基酸同源性。CPR6和CPR7都不是必需的，但CPR7的缺失会导致细胞分裂速率显著受损。这是首次证明亲环蛋白家族的一个成员是正常细胞生长所必需的。
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