Huang X, Zang Y, Wang Y, Niu G, Wen A, Ren P
Department of Traditional Chinese Medicine, Xifing Hospital, Fourth Military Medical University, Xi'an, China.
Am J Chin Med. 1996;24(2):169-76. doi: 10.1142/S0192415X96000220.
Hemodynamic actions of intravenous (iv) administration of tetramethylpyrazine phosphate (TMPP) and sodium ferulate (SF) alone or in combination were studied in anesthetized dogs. When given alone, TMPP increased left ventricular systolic pressure (LVSP), peak positive first derivative of left ventricular pressure (+LVdp/dt), coronary blood flow (CBF) and heart rate (HR) while decreasing mean aortic pressure (mAoP). SF alone did not produce any significant hemodynamic changes. When the two were administered in combination, SF antagonized dose-dependently the hemodynamic actions of TMPP. Results of this study did not support the efficacy of combined treatment of Ligusticum wallichi and Angelica root, which contain TMPP and SF respectively.
在麻醉犬中研究了单独静脉注射磷酸川芎嗪（TMPP）和阿魏酸钠（SF）及其联合应用的血流动力学作用。单独给予TMPP时，可增加左心室收缩压（LVSP）、左心室压力的最大正向一阶导数（+LVdp/dt）、冠状动脉血流量（CBF）和心率（HR），同时降低平均主动脉压（mAoP）。单独给予SF未产生任何显著的血流动力学变化。当两者联合应用时，SF剂量依赖性地拮抗TMPP的血流动力学作用。本研究结果不支持分别含有TMPP和SF的川芎和当归联合治疗的疗效。
