Huang X, Jiang Y P, Zang Y M
Xijing Hospital, Fourth Military Medical University, Xi'an.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Jun;16(6):352-4.
"Blood stasis syndrome pharmacokinetics" means the pathophysiological state of blood stasis syndrome affectes significantly the pharmacokinetic parameters. In order to provide scientific evidence for the new hypothesis, the authors studied the hemodynamic changes induced by quantitative coronary artery stenosis and pharmacokinetics of tetramethylpyrazine (TMP) in dog model with heart blood stasis (HBS) and in normal dog (for control) simultaneously. Compared with healthy dog, serum TMP concentration, drug concentration time, area under curve (AUC) and t1/2 beta in HBS dog were increased significantly (P < 0.01). The mechanism might be related with the abnormal changes in hemodynamics (indude decrease in cardiac output, left ventricular systolic pressure and coronary blood flow, etc.) caused by coronary artery stenosis.
“血瘀证药代动力学”是指血瘀证的病理生理状态对药代动力学参数有显著影响。为了给这一新假说提供科学依据，作者同时研究了定量冠状动脉狭窄诱导的血流动力学变化以及川芎嗪（TMP）在心血瘀阻（HBS）犬模型和正常犬（作为对照）中的药代动力学。与健康犬相比，HBS犬的血清TMP浓度、药物浓度时间、曲线下面积（AUC）和t1/2β显著升高（P<0.01）。其机制可能与冠状动脉狭窄引起的血流动力学异常变化（包括心输出量、左心室收缩压和冠状动脉血流量降低等）有关。
