Keltner J R, Wald L L, Christensen J D, Maas L C, Moore C M, Cohen B M, Renshaw P F
Brain Imaging Center, McLean Hospital Belmont, Cambridge, Massachusetts, USA.
Magn Reson Med. 1996 Sep;36(3):458-61. doi: 10.1002/mrm.1910360319.
A proton magnetic resonance spectral editing technique is presented that uses PRESS excitation to achieve spatially localized measurements of brain gamma-aminobutyric acid (GABA). The homonuclear difference spectroscopy technique employs a frequency selective inversion pulse to suppress the creatine resonance at 3.0 ppm. The timing of this pulse is optimized to maximize the suppression of creatine by minimizing the effect of the editing pulse on the 3.0 ppm resonances. The PRESS excitation achieves three dimensional spatial localization in a single acquisition making it less sensitive to patient motion than multiple acquisition techniques. The performance and utility of this technique were evaluated by phantom experiments and by in vivo measurements of brain GABA concentration in 10 normal subjects.
本文介绍了一种质子磁共振波谱编辑技术，该技术利用点分辨表面线圈光谱（PRESS）激发来实现对脑内γ-氨基丁酸（GABA）的空间定位测量。这种同核差异光谱技术采用频率选择性反转脉冲来抑制3.0 ppm处的肌酸共振。对该脉冲的时间进行了优化，以通过最小化编辑脉冲对3.0 ppm共振的影响来最大程度地抑制肌酸。PRESS激发在一次采集中实现三维空间定位，使其对患者运动的敏感性低于多次采集技术。通过模型实验以及对10名正常受试者脑内GABA浓度的活体测量，对该技术的性能和实用性进行了评估。
