Imaging Institute, The Cleveland Clinic, Cleveland, OH 44195, USA.
Magn Reson Imaging. 2011 Apr;29(3):374-9. doi: 10.1016/j.mri.2010.10.009. Epub 2011 Jan 12.
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain. Understanding the GABA concentration, in vivo, is important to understand normal brain function. Using MEGA point-resolved spectroscopy sequence with interleaved water scans to detect subject motion, GABA level of sensorimotor cortex was measured using a voxel identified from a functional magnetic resonance imaging scan. The GABA level in a 20×20×20-mm(3) voxel consisting of 37%±7% gray matter, 52%±12% white matter and 11%±8% cerebrospinal fluid in the sensorimotor region was measured to be 1.43±0.48 mM. In addition, using linear regression analysis, GABA concentrations within gray and white matter were calculated to be 2.87±0.61 and 0.33±0.11 mM, respectively.
γ-氨基丁酸（GABA）是大脑中主要的抑制性神经递质。了解体内 GABA 浓度对于理解正常的大脑功能非常重要。使用带有水扫描交错的 MEGA 点分辨波谱序列来检测受试者运动，使用从功能磁共振成像扫描中识别的体素来测量感觉运动皮层的 GABA 水平。在感觉运动区域内的 20×20×20mm³体素中，GABA 水平为 1.43±0.48mM，该体素由 37%±7%的灰质、52%±12%的白质和 11%±8%的脑脊液组成。此外，通过线性回归分析，计算出灰质和白质内的 GABA 浓度分别为 2.87±0.61mM 和 0.33±0.11mM。
