Purcell R H
Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0740, USA.
Princess Takamatsu Symp. 1995;25:1-13.
Hepatocellular carcinoma is one of the most important cancers worldwide and at least two hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be etiologically associated with its development. Regardless of the nature of this association, control of these two viruses would likely be effective in the prevention of hepatocellular carcinoma. The control of HBV is achievable through proper utilization of highly effective vaccines against HBV. However, the development of useful vaccines against HCV will require more knowledge about the genetic and serologic heterogeneity of this virus and the nature of the host's immune response to it.
肝细胞癌是全球最重要的癌症之一，至少两种肝炎病毒，即乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV），在病因上似乎与其发生有关。无论这种关联的性质如何，控制这两种病毒可能对预防肝细胞癌有效。通过合理使用高效的乙肝疫苗可以实现对HBV的控制。然而，开发有效的丙肝疫苗需要更多关于该病毒的基因和血清学异质性以及宿主对其免疫反应性质的知识。
