• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease.用编码糖蛋白D或糖蛋白B的DNA疫苗进行免疫，单独或联合使用，可在单纯疱疹病毒2型疾病的动物模型中诱导保护性免疫。
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11414-20. doi: 10.1073/pnas.93.21.11414.
2
The prophylactic effect of immunization with DNA encoding herpes simplex virus glycoproteins on HSV-induced disease in guinea pigs.用编码单纯疱疹病毒糖蛋白的DNA进行免疫对豚鼠单纯疱疹病毒诱导疾病的预防作用。
Vaccine. 1997 Jun;15(8):857-60. doi: 10.1016/s0264-410x(96)00246-0.
3
Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge.以表达 gB/gD 胞外结构域的人乳头瘤病毒载体进行局部单纯疱疹病毒 2（HSV-2）疫苗接种可诱导生殖器组织驻留记忆 CD8+T 细胞，并减少 HSV-2 挑战后的生殖器疾病和病毒脱落。
J Virol. 2015 Jan;89(1):83-96. doi: 10.1128/JVI.02380-14. Epub 2014 Oct 15.
4
Enhancement of protective humoral immune responses against Herpes simplex virus-2 in DNA-immunized guinea-pigs using protein boosting.使用蛋白加强免疫来增强DNA免疫的豚鼠针对单纯疱疹病毒2的保护性体液免疫反应。
FEMS Immunol Med Microbiol. 2008 Oct;54(1):18-26. doi: 10.1111/j.1574-695X.2008.00438.x. Epub 2008 Jul 21.
5
Immunogenicity, protective efficacy, and non-replicative status of the HSV-2 vaccine candidate HSV529 in mice and guinea pigs.单纯疱疹病毒2型候选疫苗HSV529在小鼠和豚鼠体内的免疫原性、保护效力及非复制状态
PLoS One. 2015 Apr 2;10(4):e0121518. doi: 10.1371/journal.pone.0121518. eCollection 2015.
6
Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpes.阻断单纯疱疹病毒 2 糖蛋白 E 的免疫逃逸作用以增强三价亚单位抗原疫苗治疗生殖器疱疹的疗效。
J Virol. 2014 Aug;88(15):8421-32. doi: 10.1128/JVI.01130-14. Epub 2014 May 14.
7
Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection.在单纯疱疹病毒2型生殖器感染小鼠模型中，不同形式的单纯疱疹复制缺陷型突变病毒作为疫苗的比较。
Virology. 2001 Sep 30;288(2):256-63. doi: 10.1006/viro.2001.1094.
8
Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs.用表达单纯疱疹病毒2型糖蛋白D的重组水痘-带状疱疹病毒进行免疫可减轻豚鼠生殖器疱疹的严重程度。
J Virol. 1995 Dec;69(12):8109-13. doi: 10.1128/JVI.69.12.8109-8113.1995.
9
Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compared to immunization with gD alone.与单独免疫 gD 相比，用包含单纯疱疹病毒 2 （HSV-2）糖蛋白 C （gC）和 gD 亚单位的疫苗进行免疫接种，可以提高对小鼠背根神经节的保护作用，并降低豚鼠 HSV-2 DNA 复发阴道脱落的频率。
J Virol. 2011 Oct;85(20):10472-86. doi: 10.1128/JVI.00849-11. Epub 2011 Aug 3.
10
A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens.一种双模态单纯疱疹病毒2型疫苗，通过使用糖蛋白C和D亚基抗原诱导强效抗体反应以及包含衣壳和被膜蛋白的腺病毒载体作为T细胞免疫原，用于预防生殖器疱疹。
J Virol. 2015 Aug;89(16):8497-509. doi: 10.1128/JVI.01089-15. Epub 2015 Jun 3.

引用本文的文献

1
A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice.一种编码单纯疱疹病毒2型糖蛋白D2（HSV-2 gD2）的无复制能力腺病毒载体具有免疫原性，且能保护小鼠免受HSV-2阴道内攻击。
PLoS One. 2024 Dec 31;19(12):e0310250. doi: 10.1371/journal.pone.0310250. eCollection 2024.
2
Prospects and perspectives for development of a vaccine against herpes simplex virus infections.针对单纯疱疹病毒感染开发疫苗的前景与展望。
Expert Rev Vaccines. 2014 Nov;13(11):1349-60. doi: 10.1586/14760584.2014.932694. Epub 2014 Jul 31.
3
The murine intravaginal HSV-2 challenge model for investigation of DNA vaccines.用于研究DNA疫苗的小鼠阴道内单纯疱疹病毒2型攻击模型。
Methods Mol Biol. 2014;1144:305-27. doi: 10.1007/978-1-4939-0428-0_21.
4
Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2.接种疫苗的小鼠和豚鼠中的泛单纯疱疹病毒 2 型 IgG 抗体与对单纯疱疹病毒 2 的保护作用相关。
PLoS One. 2013 Jun 6;8(6):e65523. doi: 10.1371/journal.pone.0065523. Print 2013.
5
A lentiviral vector-based, herpes simplex virus 1 (HSV-1) glycoprotein B vaccine affords cross-protection against HSV-1 and HSV-2 genital infections.基于慢病毒载体的单纯疱疹病毒 1 型（HSV-1）糖蛋白 B 疫苗可提供针对 HSV-1 和 HSV-2 生殖器感染的交叉保护。
J Virol. 2012 Jun;86(12):6563-74. doi: 10.1128/JVI.00302-12. Epub 2012 Apr 4.
6
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection.Vaxfectin 佐剂质粒 DNA 疫苗可改善生殖器疱疹感染小鼠模型的保护效果和免疫原性。
J Gen Virol. 2012 Jun;93(Pt 6):1305-1315. doi: 10.1099/vir.0.040055-0. Epub 2012 Mar 7.
7
Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling.通过蛋白质组范围的抗体分析发现单纯疱疹病毒 1 和 2 中的潜在诊断和疫苗抗原。
J Virol. 2012 Apr;86(8):4328-39. doi: 10.1128/JVI.05194-11. Epub 2012 Feb 8.
8
Enhanced immune response of DNA vaccine (VP1-pCDNA) adsorbed on cationic PLG for foot and mouth disease in guinea pigs.吸附于阳离子聚乳酸-乙醇酸共聚物的口蹄疫DNA疫苗（VP1-pCDNA）在豚鼠体内增强的免疫反应
Virus Genes. 2008 Aug;37(1):81-7. doi: 10.1007/s11262-008-0243-z. Epub 2008 May 31.
9
Prophylactic vaccine strategies and the potential of therapeutic vaccines against herpes simplex virus.预防性疫苗策略及治疗性疫苗抗单纯疱疹病毒的潜力
Curr Pharm Des. 2007;13(19):1975-88. doi: 10.2174/138161207781039779.
10
Recombinant vesicular stomatitis virus vectors expressing herpes simplex virus type 2 gD elicit robust CD4+ Th1 immune responses and are protective in mouse and guinea pig models of vaginal challenge.表达单纯疱疹病毒2型gD的重组水疱性口炎病毒载体可引发强烈的CD4+ Th1免疫反应，并在阴道攻击的小鼠和豚鼠模型中具有保护作用。
J Virol. 2006 May;80(9):4447-57. doi: 10.1128/JVI.80.9.4447-4457.2006.

本文引用的文献

1
Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27.
Viral Immunol. 1995;8(2):53-61. doi: 10.1089/vim.1995.8.53.
2
Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.编码gD2的核酸疫苗可保护小鼠免受2型单纯疱疹病毒疾病的侵害。
J Infect Dis. 1996 Mar;173(3):536-41. doi: 10.1093/infdis/173.3.536.
3
DNA immunization against experimental genital herpes simplex virus infection.针对实验性生殖器单纯疱疹病毒感染的DNA免疫接种
J Infect Dis. 1996 Apr;173(4):800-7. doi: 10.1093/infdis/173.4.800.
4
Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge.用1型单纯疱疹病毒糖蛋白D DNA对小鼠进行疫苗接种，对致死性HSV-1攻击产生的保护水平较低。
Antiviral Res. 1995 Oct;28(2):147-57. doi: 10.1016/0166-3542(95)00045-n.
5
Protection against papillomavirus with a polynucleotide vaccine.用多核苷酸疫苗预防乳头瘤病毒。
J Infect Dis. 1996 Feb;173(2):314-20. doi: 10.1093/infdis/173.2.314.
6
Gene inoculation generates immune responses against human immunodeficiency virus type 1.基因接种可引发针对1型人类免疫缺陷病毒的免疫反应。
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4156-60. doi: 10.1073/pnas.90.9.4156.
7
Heterologous protection against influenza by injection of DNA encoding a viral protein.通过注射编码病毒蛋白的DNA实现对流感的异源保护。
Science. 1993 Mar 19;259(5102):1745-9. doi: 10.1126/science.8456302.
8
Evaluation of HPMPC therapy for primary and recurrent genital herpes in mice and guinea pigs.膦甲酸钠治疗小鼠和豚鼠原发性及复发性生殖器疱疹的评估。
Antiviral Res. 1993 May;21(1):59-72. doi: 10.1016/0166-3542(93)90067-s.
9
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.单纯疱疹病毒γ1 34.5缺失突变体在啮齿动物模型中的复制、潜伏建立及诱导再激活
J Clin Invest. 1993 Jun;91(6):2837-43. doi: 10.1172/JCI116527.
10
Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein B.用表达单纯疱疹病毒糖蛋白B的重组腺病毒进行鼻内免疫后的黏膜免疫与保护作用
J Infect Dis. 1993 Sep;168(3):622-9. doi: 10.1093/infdis/168.3.622.

用编码糖蛋白D或糖蛋白B的DNA疫苗进行免疫，单独或联合使用，可在单纯疱疹病毒2型疾病的动物模型中诱导保护性免疫。

Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease.

作者信息

McClements W L, Armstrong M E, Keys R D, Liu M A

机构信息

Department of Virus and Cell Biology, Merck Research Laboratories, West Point, PA 19486, USA.

出版信息

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11414-20. doi: 10.1073/pnas.93.21.11414.

DOI:10.1073/pnas.93.21.11414
PMID:8876149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC38071/
Abstract

DNA vaccines expressing herpes simplex virus type 2 (HSV-2) full-length glycoprotein D (gD), or a truncated form of HSV-2 glycoprotein B (gB) were evaluated for protective efficacy in two experimental models of HSV-2 infection. Intramuscular (i.m.) injection of mice showed that each construction induced neutralizing serum antibodies and protected the mice from lethal HSV-2 infection. Dose-titration studies showed that low doses (< or = 1 microgram) of either DNA construction induced protective immunity, and that a single immunization with the gD construction was effective. The two DNAs were then tested in a low-dosage combination in guinea pigs. Immune sera from DNA-injected animals had antibodies to both gD and gB, and virus neutralizing activity. When challenged by vaginal infection with HSV-2, the DNA-immunized animals were significantly protected from primary genital disease.

摘要

在两种单纯疱疹病毒2型（HSV-2）感染实验模型中，对表达HSV-2全长糖蛋白D（gD）或HSV-2糖蛋白B（gB）截短形式的DNA疫苗的保护效力进行了评估。对小鼠进行肌肉注射显示，每种构建体均可诱导产生中和血清抗体，并保护小鼠免受致死性HSV-2感染。剂量滴定研究表明，低剂量（≤1微克）的任何一种DNA构建体均可诱导保护性免疫，并且单次接种gD构建体即有效。然后在豚鼠中对这两种DNA进行低剂量联合测试。来自注射DNA动物的免疫血清具有针对gD和gB的抗体以及病毒中和活性。当通过阴道感染HSV-2进行攻击时，经DNA免疫的动物受到显著保护，免受原发性生殖器疾病的侵害。