Vargas-Díez E, Buezo G F, Aragües M, Daudén E, De Ory F
Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.
Int J Dermatol. 1996 Sep;35(9):626-32. doi: 10.1111/j.1365-4362.1996.tb03686.x.
Papular-purpuric gloves-and-socks syndrome (PPGSS) is a recently described dermatosis in which human parvovirus B19 (HPV B19) has been implicated as etiologic agent; however, it is suspected that PPGSS may be caused by various agents. This study was designed to survey the general characteristics of PPGSS and to determine the role of HPV B19 in its etiology.
We analyzed data from 21 patient and examined serum samples from three new cases for various viruses.
The PPGSS displays a striking uniform clinical pattern. Histologic and immunofluorescence findings are non-specific. Seroconversion of HPV B19 was reported in six cases and confirmed in two of our patients. In only one case was a possible causative role of Coxsackie virus B6 suggested consistently.
The PPGSS represents a distinctive dermatosis and a manifestation of HPV B19 infection. Unlike erythema infectiosum, anti-HPV B19 antibodies seem to develop later after onset of the skin eruption and while viremia is still present.
丘疹紫癜性手套和袜子综合征（PPGSS）是一种最近才被描述的皮肤病，其中人细小病毒B19（HPV B19）被认为是病因；然而，有人怀疑PPGSS可能由多种因素引起。本研究旨在调查PPGSS的一般特征，并确定HPV B19在其病因学中的作用。
我们分析了21例患者的数据，并检测了3例新病例血清样本中的多种病毒。
PPGSS呈现出显著一致的临床模式。组织学和免疫荧光检查结果无特异性。6例报告有HPV B19血清学转换，我们的2例患者得到证实。仅在一例中始终提示柯萨奇病毒B6可能具有致病作用。
PPGSS是一种独特的皮肤病，是HPV B19感染的一种表现。与传染性红斑不同，抗HPV B19抗体似乎在皮疹发作后较晚出现，且病毒血症仍存在时才产生。
