挪威癫痫女性新生儿的脊柱裂和唇裂：与抗惊厥药物使用相关的变化
Spina bifida and cleft lip among newborns of Norwegian women with epilepsy: changes related to the use of anticonvulsants.
作者信息
King P B, Lie R T, Irgens L M
机构信息
Medical Birth Registry of Norway, University of Bergen, Norway.
出版信息
Am J Public Health. 1996 Oct;86(10):1454-6. doi: 10.2105/ajph.86.10.1454.
OBJECTIVES
This study examined the connection between the use of anticonvulsants for epilepsy during or before pregnancy and the risk of spina bifida and cleft lip in newborns.
METHODS
Among mothers registered from 1967 to 1992 by the Medical Birth Registry of Norway, 7588 who had epilepsy were identified and their newborns' prevalence of spina bifida and cleft lip examined.
RESULTS
The odds ratio of spina bifida in children of mothers with epilepsy compared with other children increased from 1.5 in 1967 through 1980 (95% confidence interval [CI] = 0.3, 4.5) to 4.4 in 1981 through 1992 (95% CI = 2.0, 8.5). The odds ratio of cleft lip, however, decreased from 3.0 before 1981 (95% CI = 1.6, 5.1) to 1.1 after 1981 (95% CI = 0.4, 2.3).
CONCLUSIONS
This shift toward more serious birth defects is consistent with the different teratogenic effects of newer and older anticonvulsants.
目的
本研究探讨孕期或孕前使用抗癫痫药物与新生儿脊柱裂和唇裂风险之间的联系。
方法
在挪威医疗出生登记处1967年至1992年登记的母亲中，确定了7588名患有癫痫的母亲，并检查了她们新生儿的脊柱裂和唇裂患病率。
结果
癫痫母亲的孩子患脊柱裂的比值比与其他孩子相比，从1967年至1980年的1.5（95%置信区间[CI]=0.3，4.5）增加到1981年至1992年的4.4（95%CI=2.0，8.5）。然而，唇裂的比值比从1981年前的3.0（95%CI=1.6，5.1）降至1981年后的1.1（95%CI=0.4，2.3）。
结论
这种向更严重出生缺陷的转变与新旧抗惊厥药物不同的致畸作用一致。
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