Hiilesmaa V K, Teramo K, Granström M L, Bardy A H
Br Med J (Clin Res Ed). 1983 Aug 27;287(6392):577-9. doi: 10.1136/bmj.287.6392.577.
Serum folate concentrations, blood counts, and antiepileptic drug concentrations were measured during 133 pregnancies of 125 women with epilepsy. There was an inverse correlation between serum folate concentrations and concentrations of phenytoin and phenobarbitone. The number of epileptic seizures during pregnancy showed no association with serum folate concentrations. No cases of maternal tissue folate deficiency or fetal damage attributable to low maternal serum folate were observed. Maternal serum folate concentrations for infants with structural birth defects, "fetal hydantoin syndrome," or perinatal death were similar to those for healthy babies. A low dose (100 to 1000 micrograms daily) of folate supplement appeared sufficient for pregnant women with epilepsy despite the antifolic action of antiepileptic medication. Monitoring folate concentrations in pregnant women with high serum concentrations of phenytoin or phenobarbitone is recommended.
在125名癫痫女性的133次妊娠期间，对血清叶酸浓度、血细胞计数和抗癫痫药物浓度进行了测量。血清叶酸浓度与苯妥英和苯巴比妥浓度之间呈负相关。孕期癫痫发作次数与血清叶酸浓度无关。未观察到因母体血清叶酸水平低而导致的母体组织叶酸缺乏或胎儿损伤病例。患有结构出生缺陷、“胎儿乙内酰脲综合征”或围产期死亡的婴儿的母体血清叶酸浓度与健康婴儿相似。尽管抗癫痫药物有抗叶酸作用，但低剂量（每日100至1000微克）的叶酸补充剂似乎对癫痫孕妇足够。建议对苯妥英或苯巴比妥血清浓度高的孕妇监测叶酸浓度。
