Savitz D A, Brett K M, Baird N J, Tse C K
Department of Epidemiology, University of North Carolina, Chapel Hill 27599, USA.
Am J Ind Med. 1996 Sep;30(3):307-16. doi: 10.1002/(SICI)1097-0274(199609)30:3<307::AID-AJIM9>3.0.CO;2-V.
To address potential reproductive hazards in textile manufacturing, we conducted a community-based case-control study in central North Carolina. Miscarriage cases were identified from medical records (280 interviewed cases): preterm delivery cases and term, normal birth weight controls (454 and 605, respectively) were identified from area hospitals. Exposures were based on job title, an interview concerning textile-related exposures, expert imputation of exposure based on job titles and interviews, and self-reported exposures by women. Relative to women and men working in nonhazardous occupations, workers in the textile industry were not at increased risk of miscarriage or preterm delivery, with the possible exception of preterm delivery among women and men employed in sectors other than knitting and yarn mills and men employed in yarn mills. Inferred exposures to specific agents were also not associated with adverse pregnancy outcome. Subject to uncertainty in exposure assessment and nonresponse, these data indicate an absence of adverse effects of the textile workplace environment on these pregnancy outcomes.
为了研究纺织制造业中潜在的生殖危害，我们在北卡罗来纳州中部开展了一项基于社区的病例对照研究。从医疗记录中识别出流产病例（280例接受访谈）：从当地医院识别出早产病例以及足月、正常出生体重的对照（分别为454例和605例）。暴露情况基于工作岗位、关于与纺织相关暴露的访谈、根据工作岗位和访谈由专家估算的暴露情况以及女性的自我报告暴露情况。与从事非危险职业的女性和男性相比，纺织行业的工人流产或早产风险并未增加，但针织厂和纱厂以外部门工作的女性和男性以及纱厂工作的男性的早产情况可能除外。推断的特定物质暴露也与不良妊娠结局无关。考虑到暴露评估中的不确定性和无应答情况，这些数据表明纺织工作场所环境对这些妊娠结局没有不良影响。
