Kwang J, Wilson R, Yang S, He Y
U.S. Meat Animal Research Center, U.S. Department of Agriculture, Clay Center, Nebraska 68933, USA.
Clin Diagn Lab Immunol. 1996 Sep;3(5):523-6. doi: 10.1128/cdli.3.5.523-526.1996.
The amino acid sequences responsible for H7 and H23 flagellum serology have been identified by using a genetic approach. The H7-specific domain was located between amino acids 352 and 374 of the H7 flagellin. The sequencing data also demonstrated that the difference between the H7 and H23 flagellins in this region results from a single substitution at amino acid 366 (Ser-->Thr). The common epitopes for H7 and H23 were located between amino acids 284 and 366.
通过遗传学方法已确定了负责H7和H23鞭毛血清学的氨基酸序列。H7特异性结构域位于H7鞭毛蛋白的第352至374位氨基酸之间。测序数据还表明,该区域H7和H23鞭毛蛋白之间的差异是由第366位氨基酸的单个取代(丝氨酸→苏氨酸)引起的。H7和H23的共同表位位于第284至366位氨基酸之间。