Kuiper-Kramer E P, Huisman C M, van Raan J, van Eijk H G
Klinisch Chemisch Laboratorium, Sophia Ziekenhuis, Zwolle, The Netherlands.
Eur J Clin Chem Clin Biochem. 1996 Aug;34(8):645-9. doi: 10.1515/cclm.1996.34.8.645.
In this study the analytical performances of two recently introduced assays for soluble transferrin receptors in serum were tested. The Ramco transferrin assay was compared with the Eurogenetics assay. In a small clinical study serum samples from patients with anaemia of chronic disease, iron deficiency and myelodysplastic syndrome were analysed, as well as sera from healthy volunteers. The analytical performances of the Ramco assay were found to be acceptable. In the Eurogenetics test however, inter-assay imprecision and the end of run drift were unacceptably high. We were able to confirm that in patients with uncomplicated iron deficiency the concentration of soluble transferrin receptors is higher than in healthy volunteers. In cases of anaemia of chronic and inflammatory disease, the levels of soluble transferrin receptors in serum are slightly, but not significantly, higher than in normal subjects. Measurement of soluble transferrin receptors in serum provides a good differentiation between anaemia of chronic disease and iron deficiency.
在本研究中，对最近推出的两种血清可溶性转铁蛋白受体检测方法的分析性能进行了测试。将Ramco转铁蛋白检测法与欧洲基因公司检测法进行了比较。在一项小型临床研究中，分析了患有慢性病贫血、缺铁性贫血和骨髓增生异常综合征患者的血清样本，以及健康志愿者的血清。发现Ramco检测法的分析性能是可接受的。然而，在欧洲基因公司的检测中，批间不精密度和运行结束时的漂移过高，令人无法接受。我们能够证实，在无并发症的缺铁患者中，可溶性转铁蛋白受体的浓度高于健康志愿者。在慢性和炎症性疾病贫血的病例中，血清中可溶性转铁蛋白受体的水平略高于正常受试者，但差异不显著。血清中可溶性转铁蛋白受体的测量有助于很好地区分慢性病贫血和缺铁性贫血。
