Kuiper-Kramer E P, Coenen J L, Huisman C M, Abbes A, van Raan J, van Eijk H G
Sophia Hospital, Zwolle, The Netherlands.
Acta Haematol. 1998;99(1):8-11. doi: 10.1159/000040707.
The expression of transferrin receptors on the cell membrane of erythroblasts was analysed with flow cytometry in patients with different forms of anaemia. At the same time the concentration of soluble transferrin receptors (sTfRs) was analysed in serum. It was shown that only in iron deficiency a high concentration of sTfRs in serum could be explained with an increased expression of transferrin receptors on the erythroblastic membrane. In anaemia of chronic disease and myelodysplasia a discrepancy between a low expression on the cell membrane and normal or elevated serum values was seen. From this study we conclude that the concentration of sTfRs in serum does not only depend on the expression of transferrin receptors on the erythroblasts but also on the erythroid activity.
采用流式细胞术分析了不同类型贫血患者成红细胞细胞膜上转铁蛋白受体的表达情况。同时，对血清中可溶性转铁蛋白受体（sTfRs）的浓度进行了分析。结果表明，只有在缺铁性贫血中，血清中高浓度的sTfRs可以用成红细胞膜上转铁蛋白受体表达增加来解释。在慢性病贫血和骨髓增生异常综合征中，观察到细胞膜上低表达与正常或升高的血清值之间存在差异。从这项研究中我们得出结论，血清中sTfRs的浓度不仅取决于成红细胞上转铁蛋白受体的表达，还取决于红系活性。
