Chabaud M, Le Cann P, Mayelo V, Leboulleux D, Diallo A S, Enogat N, Afoutou J M, Anthonioz P, Coll-Seck A M, Coursaget P
Institut de Virologie de Tours, Faculté de Pharmacie, CHRU Bretonneau, Tours, France.
J Med Virol. 1996 Aug;49(4):259-63. doi: 10.1002/(SICI)1096-9071(199608)49:4<259::AID-JMV1>3.0.CO;2-2.
In order to analyse human papillomavirus (HPV) infection in the Senegalese population, HPV DNA was sought in 65 women with evidence of cervical cytological abnormality and in 72 pregnant women. Ninety-four percent of the patients were positive for HPV DNA as compared to 24% of pregnant women. HPV 16 was detected in cervical smears in 42% of cases, HPV 18 in 39%, HPV 6 in 26%, HPV 11 in 15%, HPV 45 in 10%, HPV 52 in 3%, and HPV 31, HPV 33 and HPV 68 in 1.5%. HPV 16 and HPV 18 were detected in 16% and 7% respectively of pregnant women. HPV DNA of unknown type was detected in 6% of cases, and multiple HPV infections were observed in 28% of cases. Low risk genital HPVs (6/11) were detected in smaller proportions (17%) among high grade squamous intraepithelial lesions (SILs) than the low grade SILs (43%). High risk HPVs (16/18) were detected in high proportions both in low and high grade SIL lesions, though the highest frequency (70%) was observed among patients with high grade lesions. In conclusion, the results confirm that HPV infections are frequent in Senegal and that HPV 18 and 45 are detected in a high proportion of patients in Africa.
为分析塞内加尔人群中的人乳头瘤病毒（HPV）感染情况，对65例有宫颈细胞学异常证据的女性及72例孕妇进行了HPV DNA检测。患者中94%的HPV DNA呈阳性，而孕妇中这一比例为24%。宫颈涂片检测中，42%的病例检测到HPV 16，39%检测到HPV 18，26%检测到HPV 6，15%检测到HPV 11，10%检测到HPV 45，3%检测到HPV 52，1.5%检测到HPV 31、HPV 33和HPV 68。孕妇中分别有16%和7%检测到HPV 16和HPV 18。6%的病例检测到未知类型的HPV DNA，28%的病例观察到多重HPV感染。低级别鳞状上皮内病变（SIL）中低风险生殖器HPV（6/11）的检出比例（17%）低于高级别SIL（43%）。高风险HPV（16/18）在低级别和高级别SIL病变中检出比例均较高，不过在高级别病变患者中观察到的频率最高（70%）。总之，结果证实塞内加尔HPV感染很常见，且非洲高比例患者中检测到HPV 18和45。
