从患有呼吸道疾病的牛的鼻拭子中分离出的细菌和支原体的抗菌剂的分数抑制浓度指数。

The fractional inhibitory concentration index of antimicrobial agents for bacteria and Mycoplasma isolated from the nasal swabs of cattle with respiratory diseases.

作者信息

Katoh T, Sakai J, Itagaki M, Watanabe E, Watanabe D, Ogata Y

机构信息

Veterinary Clinical Training Center, Yamagata Prefectural Federation of Agricultural Mutual Aid Associations, Japan.

出版信息

J Vet Med Sci. 1996 Aug;58(8):781-2. doi: 10.1292/jvms.58.781.

DOI:10.1292/jvms.58.781

PMID:8877979

Abstract

We investigated the effect of thiamphenicol plus lincomycin (TP + LCM) and thiamphenicol plus tylosin (TP + TS) combinations using checker board method on the growth of Pasteurella (P.) multocida, P. haemolytica and Mycoplasma (M.) bovis by calculating the fractional inhibitory concentration index (FIC index). The results showed that the FIC indexes of the TP + LCM combination for P. multocida, P. haemolytica and M. bovis were 0.36 +/- 0.10, 0.72 +/- 0.09 and 0.81 +/- 0.18, respectively. The FIC indexes of the TP + TS combination for P. multocida, P. haemolytica, and M. bovis were 0.79 +/- 0.20, 0.66 +/- 0.11 and 0.32 +/- 0.14, respectively. Thus, these combinations are assumed to have a more synergistic or additive effect on bacteria growth than a single antimicrobial agent.

摘要

我们采用棋盘法研究了甲砜霉素联合林可霉素（TP + LCM）以及甲砜霉素联合泰乐菌素（TP + TS）对多杀性巴氏杆菌、溶血巴氏杆菌和牛支原体生长的影响，并计算了部分抑菌浓度指数（FIC指数）。结果显示，TP + LCM组合对多杀性巴氏杆菌、溶血巴氏杆菌和牛支原体的FIC指数分别为0.36±0.10、0.72±0.09和0.81±0.18。TP + TS组合对多杀性巴氏杆菌、溶血巴氏杆菌和牛支原体的FIC指数分别为0.79±0.20、0.66±0.11和0.32±0.14。因此，相较于单一抗菌剂，这些组合对细菌生长具有更强的协同或相加作用。