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前列腺素E2在甲状腺甲状旁腺切除的大鼠而非完整大鼠中诱发高钙血症。

Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats.

作者信息

Robertson R P, Baylink D J

出版信息

Prostaglandins. 1977 Jun;13(6):1141-5. doi: 10.1016/0090-6980(77)90140-x.

DOI:10.1016/0090-6980(77)90140-x
PMID:887802
Abstract

Prostaglandin E2 was infused into thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 +/- 0.21 mg/dl (x +/- SE, p less than .001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.

摘要

将前列腺素E2注入甲状腺甲状旁腺切除(TPTX)大鼠和完整大鼠的胸主动脉。TPTX组中,循环钙在30分钟时显著升高,到90分钟时增加了1.5±0.21mg/dl(x±SE,p<0.001)。在完整大鼠中未观察到钙的增加。据推测,之前在注入PGE2期间未能证明高钙血症可能是由于降钙素的反调节作用。

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Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats.前列腺素E2在甲状腺甲状旁腺切除的大鼠而非完整大鼠中诱发高钙血症。
Prostaglandins. 1977 Jun;13(6):1141-5. doi: 10.1016/0090-6980(77)90140-x.
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引用本文的文献

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Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.携带VX2癌的兔肠道介导的高钙血症:肿瘤诱导高钙血症的新机制
Proc Natl Acad Sci U S A. 1982 Jan;79(2):640-4. doi: 10.1073/pnas.79.2.640.
2
The pathophysiology and clinical aspects of hypercalcemic disorders.高钙血症疾病的病理生理学与临床方面
West J Med. 1978 Oct;129(4):278-320.
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Localization of prostaglandin synthetase in chicken epiphyseal cartilage.前列腺素合成酶在鸡骨骺软骨中的定位
Calcif Tissue Res. 1978 Dec 8;26(3):227-36. doi: 10.1007/BF02013263.