Wicki R, Schäfer B W, Erne P, Heizmann C W
Department of Pediatrics, University of Zürich, Switzerland.
Biochem Biophys Res Commun. 1996 Oct 14;227(2):594-9. doi: 10.1006/bbrc.1996.1551.
Here we report the characterization of the human S100A13 cDNA coding for a novel calcium-binding protein belonging to the S100 protein family. The predicted S100A13 protein shows sequence homologies to other S100 proteins between 50.5% (to S100A5) and 59.3% (to S100A12). High mRNA amounts were found in skeletal muscle, heart, kidney, ovary, small intestine and pancreas. Since twelve S100 genes are clustered on human chromosome 1q21, we determined the chromosomal localization of the human S100A13. It co-localizes with S100A1 on the cluster. Furthermore, we characterized the cDNA sequence coding for the mouse homolog of S100A13. Similar to the putative human protein, mouse S100A13 is composed of 98 amino acids displaying a homology of 86.7% compared to human S100A13.
在此，我们报告了人类S100A13 cDNA的特征，该cDNA编码一种属于S100蛋白家族的新型钙结合蛋白。预测的S100A13蛋白与其他S100蛋白的序列同源性在50.5%（与S100A5）至59.3%（与S100A12）之间。在骨骼肌、心脏、肾脏、卵巢、小肠和胰腺中发现了高含量的mRNA。由于12个S100基因聚集在人类染色体1q21上，我们确定了人类S100A13的染色体定位。它与S100A1在该基因簇上共定位。此外，我们对编码小鼠S100A13同源物的cDNA序列进行了特征分析。与推测的人类蛋白相似，小鼠S100A13由98个氨基酸组成，与人类S100A13的同源性为86.7%。
