糖皮质激素在炎症性增生性皮肤病中可降低花生四烯酸和羟基二十碳四烯酸的水平。
Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids.
作者信息
Hammarström S, Hamberg M, Duell E A, Stawiski M A, Anderson T F, Voorhees J J
出版信息
Science. 1977 Sep 2;197(4307):994-6. doi: 10.1126/science.887938.
PMID:887938
Abstract
Psoriasis is a prototype of several common, glucocorticoid responsive, inflammatory proliferative skin diseases. Within 28 hours, glucocorticoid reduced the increased concentration of free arachidonic acid in diseased tissue. This reduction was observed prior to visible improvement of disease and may be an important molecular mechanism for the therapeutic efficacy of glucocorticoids in psoriasis and similar inflammatory diseases.
摘要
银屑病是几种常见的、对糖皮质激素有反应的炎症性增殖性皮肤病的典型代表。在28小时内，糖皮质激素降低了患病组织中游离花生四烯酸浓度的升高。这种降低在疾病明显改善之前就已观察到，可能是糖皮质激素对银屑病及类似炎症性疾病治疗效果的重要分子机制。
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