聚甲基丙烯酸甲酯复合材料：生物活性玻璃和羟基磷灰石表面的骨形成紊乱。

Polymethylmethacrylate composites: disturbed bone formation at the surface of bioactive glass and hydroxyapatite.

作者信息

Heikkilä J T, Aho A J, Kangasniemi I, Yli-Urpo A

机构信息

Department of Surgery, University of Turku, Finland.

出版信息

Biomaterials. 1996 Sep;17(18):1755-60. doi: 10.1016/0142-9612(95)00326-6.

DOI:10.1016/0142-9612(95)00326-6

PMID:8879512

Abstract

The effects of polymethylmethacrylate on bone formation were studied alone and as composites in combination with hydroxyapatite and bioactive glass in the rabbit subchondral femur. Radiographs, histology, computer assisted histomorphometry, scanning electron microscopy and energy dispersive X-ray analysis were used for evaluation. A total of 60 cones were implanted for 3, 6 and 12 weeks. The composite cones consisted of granules of bioactive glass (S56.5P4) or hydroxyapatite embedded in polymethylmethacrylate. Pure polymethylmethacrylate cones served as controls. At the interface of the cones, bone contact was observed only when bioactive glass or hydroxyapatite was present at the cone surface. Fibrous tissue was always found at the polymethylmethacrylate-tissue interface. The osteoconductive bone formation at the surface of bioactive glass and hydroxyapatite was disturbed by polymethylmethacrylate. It seemed to resist bone formation at the interface of both bioactive glass and hydroxyapatite. However, bioactive glass was better able to withstand the detrimental effect of polymethylmethacrylate than hydroxyapatite.

摘要

在兔股骨软骨下区域，研究了聚甲基丙烯酸甲酯单独以及与羟基磷灰石和生物活性玻璃复合时对骨形成的影响。采用X线片、组织学、计算机辅助组织形态计量学、扫描电子显微镜和能量色散X射线分析进行评估。总共植入60个椎体，分别观察3周、6周和12周。复合椎体由嵌入聚甲基丙烯酸甲酯中的生物活性玻璃（S56.5P4）颗粒或羟基磷灰石颗粒组成。纯聚甲基丙烯酸甲酯椎体作为对照。在椎体界面处，仅当椎体表面存在生物活性玻璃或羟基磷灰石时才观察到骨接触。在聚甲基丙烯酸甲酯与组织的界面处总是发现纤维组织。聚甲基丙烯酸甲酯干扰了生物活性玻璃和羟基磷灰石表面的骨传导性骨形成。它似乎在生物活性玻璃和羟基磷灰石两者的界面处抑制骨形成。然而，与羟基磷灰石相比，生物活性玻璃更能耐受聚甲基丙烯酸甲酯的有害作用。