将莫舍尔方法应用于含有邻二醇的产乙酸素。来自番荔枝科罗林果的新型生物活性产乙酸素muricatetrocin C以及罗林果霉素A和B的绝对构型。

Applying Mosher's method to acetogenins bearing vicinal diols. The absolute configurations of muricatetrocin C and rollidecins A and B, new bioactive acetogenins from Rollinia mucosa.

作者信息

Shi G, Gu Z M, He K, Wood K V, Zeng L, Ye Q, MacDougal J M, McLaughlin J L

机构信息

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Bioorg Med Chem. 1996 Aug;4(8):1281-6. doi: 10.1016/0968-0896(96)00114-9.

DOI:10.1016/0968-0896(96)00114-9

PMID:8879549

Abstract

Muricatetrocin C (1), rollidecin A (2), and rollidecin B (3), three new bioactive annonaceous acetogenins bearing vicinal diols, were isolated from the leaves of Rollinia mucosa (Annonaceae) using activity-directed fractionation. The total structural elucidations of 1-3, including the absolute stereochemistries of the vicinal diols, were achieved by analyzing their per-Mosher ester derivatives. All three compounds showed potent and selective inhibitory effects against several human cancer cell lines.

摘要

从番荔枝科植物多鳞番荔枝（Rollinia mucosa）的叶子中，通过活性导向分级分离法分离出了三种新的具有邻二醇结构的生物活性番荔枝内酯——刺果番荔枝四素C（1）、罗利地辛A（2）和罗利地辛B（3）。通过分析它们的全莫舍尔酯衍生物，完成了对1 - 3的全结构解析，包括邻二醇的绝对立体化学结构。这三种化合物对几种人类癌细胞系均表现出强效且选择性的抑制作用。