肝硬化和阻塞性黄疸时肝功能性储备降低，特别涉及组织学形态计量分析和半乳糖清除能力

Reduced hepatic functional reserve in cirrhosis and obstructive jaundice with special reference to histological morphometric analysis and galactose elimination capacity.

作者信息

Kaiho T, Miyazaki M, Ito H, Ambiru S, Shimizu H, Togawa A, Ohtsuka M, Shiobara M, Shimizu Y, Sasada K, Yoshioka S, Yoshidome H, Nakajima N

机构信息

First Department of Surgery, School of Medicine, Chiba University, Japan.

出版信息

Eur Surg Res. 1996;28(5):333-40. doi: 10.1159/000129474.

DOI:10.1159/000129474

PMID:8880122

Abstract

To evaluate liver dysfunction in patients with obstructive jaundice (OJ), morphological and functional hepatic mass was analyzed in comparison with cirrhosis (LC). Total hepatic parenchymal ratio (THPR) was estimated by morphometric analysis and hepatic functional mass by galactose tolerance test (GaTT) in 30 patients who underwent hepatectomy. The value of GaTT in patients with LC was remarkably depressed compared to those with normal liver function (p < 0.001). It was also depressed in OJ (p < 0.05 vs. normal liver), but less than in LC (p < 0.05). However, THPR decreased only in LC (p < 0.05 vs. either normal liver or OJ). A significant correlation between the value of GaTT and THPR was revealed in patients with LC, but not in OJ. These results suggested that liver dysfunction in OJ was independent of the decreased number of hepatocytes, differing from LC.

摘要

为评估梗阻性黄疸（OJ）患者的肝功能障碍，将肝实质形态和功能与肝硬化（LC）患者进行比较分析。对30例行肝切除术的患者，通过形态计量分析估计肝实质总面积比（THPR），并通过半乳糖耐量试验（GaTT）评估肝功能性体积。与肝功能正常者相比，LC患者的GaTT值显著降低（p < 0.001）。OJ患者的GaTT值也降低（与正常肝脏相比，p < 0.05），但低于LC患者（p < 0.05）。然而，仅LC患者的THPR降低（与正常肝脏或OJ相比，p < 0.05）。LC患者中GaTT值与THPR之间存在显著相关性，但OJ患者中未发现。这些结果表明，OJ患者的肝功能障碍与肝细胞数量减少无关，这与LC不同。