Kaiho T, Miyazaki M, Udagawa I, Koshikawa H, Iinuma K, Ito H, Kimura F, Matsumoto J, Isono T, Suzuki H
Department of Surgery, Chiba University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1991 Mar;88(3):689-97.
Hepatic functional mass was evaluated in patients with obstructive jaundice using the galactose tolerance test (GaTT), which reflected cytosolic function of hepatocyte. The T-1/2 values as an index on the GaTT were significantly prolonged in patients with obstructive jaundice in comparison with control subjects whether before or after percutaneous transhepatic biliary drainage (PTBD). But in each cases, some showed nearly normal GaTT-T/2 value and others showed severely prolonged value. Patients with obstructive jaundice could be divided into two groups according to the GaTT-T/2 value before PTBD. The decreasing rate of serum bilirubin level "b" after PTBD was significantly fair in the group A patients (good GaTT-T/2 value before PTBD) than the group B (poor GaTT-T/2 value before PTBD) (P less than 0.05). It was that GaTT-T/2 before PTBD which represented hepatic cytosolic functional mass could predict the effect of PTBD in patients with obstructive jaundice.
采用半乳糖耐量试验（GaTT）对梗阻性黄疸患者的肝功能性体积进行评估，该试验反映肝细胞的胞质功能。无论在经皮经肝胆道引流（PTBD）之前还是之后，梗阻性黄疸患者作为GaTT指标的T-1/2值与对照受试者相比均显著延长。但在每种情况下，一些患者的GaTT-T/2值接近正常，而另一些患者的值则严重延长。根据PTBD前的GaTT-T/2值，梗阻性黄疸患者可分为两组。PTBD后，A组患者（PTBD前GaTT-T/2值良好）血清胆红素水平“b”的下降率明显高于B组（PTBD前GaTT-T/2值较差）（P<0.05）。即PTBD前代表肝细胞胞质功能体积的GaTT-T/2可以预测梗阻性黄疸患者PTBD的效果。
