艾滋病相关卡波西肉瘤的发病机制。病毒病因学证据。

Pathogenesis of AIDS--related Kaposi's sarcoma. Evidence of a viral etiology.

作者信息

Miles S A

机构信息

Department of Medicine, University of California, Los Angeles, School of Medicine, USA.

出版信息

Hematol Oncol Clin North Am. 1996 Oct;10(5):1011-21. doi: 10.1016/s0889-8588(05)70381-6.

DOI:10.1016/s0889-8588(05)70381-6

PMID:8880193

Abstract

Kaposi's sarcoma is the most common malignancy in patients with HIV infection. New studies point to the involvement of a new human Kaposi's sarcoma herpes virus (KSHV) as a transforming agent. After transformation, cytokine perturbations facilitate growth and in some cases clonal growth occurs. This results in a malignancy with devastating clinical consequences. A clear understanding of the mechanism of transformation by KSHV will lead to better therapies.

摘要

卡波西肉瘤是艾滋病病毒感染者中最常见的恶性肿瘤。新的研究表明，一种新型人类卡波西肉瘤疱疹病毒（KSHV）作为一种转化因子参与其中。转化后，细胞因子紊乱促进生长，在某些情况下会出现克隆性生长。这导致了一种具有毁灭性临床后果的恶性肿瘤。清楚了解KSHV的转化机制将带来更好的治疗方法。