Forsyth P A, DeAngelis L M
Department of Medicine, Tom Baker Cancer Centre, Foothills Hospital, Calgary, Alberta, Canada.
Hematol Oncol Clin North Am. 1996 Oct;10(5):1125-34. doi: 10.1016/s0889-8588(05)70388-9.
Primary central nervous system (CNS) lymphoma is the most common brain tumor in patients with AIDS and occurs in about 10% of this population. CT/MR scan usually demonstrates single or multiple contrast enhancing masses that are radiographically indistinguishable from other CNS processes such as toxoplasmosis. Brain biopsy, positive cerebrospinal fluid (CSF) cytology, or possibly the demonstration of Epstein-Barr viral DNA in the CSF can establish the diagnosis. Cranial radiotherapy (RT) has been the cornerstone of therapy and produces responses in most patients, but their median survival is still only a few months. The addition of chemotherapy to RT may prolong survival in a sub-group of patients.
原发性中枢神经系统（CNS）淋巴瘤是艾滋病患者中最常见的脑肿瘤，约10%的该人群会发生此病。CT/MR扫描通常显示单个或多个强化肿块，影像学上与其他中枢神经系统病变（如弓形虫病）难以区分。脑活检、脑脊液（CSF）细胞学检查呈阳性，或者脑脊液中可能检测到爱泼斯坦-巴尔病毒DNA可确诊。颅脑放疗（RT）一直是治疗的基石，大多数患者会有反应，但他们的中位生存期仍只有几个月。放疗联合化疗可能会延长部分患者的生存期。
