Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.
作者信息
Crampton R F, Gray T J, Grasso P, Parke D V
出版信息
Toxicology. 1977 Jun;7(3):307-26. doi: 10.1016/0300-483x(77)90050-6.
PMID:888148
Abstract
摘要
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Long-term studies on chemically induced liver enlargement in the rat. II. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and Ponceau MX.大鼠化学诱导性肝脏肿大的长期研究。II. 由黄樟素和丽春红MX引起的微粒体酶的短暂诱导导致肝损伤和结节性增生。
Toxicology. 1977 Jun;7(3):307-26. doi: 10.1016/0300-483x(77)90050-6.
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Long-term studies on chemically induced liver enlargement in the rat. III. Structure and behaviour of the hepatic nodular lesions induced by Ponceau MX.大鼠化学诱导性肝肿大的长期研究。III. 丽春红MX诱导的肝结节性病变的结构与行为
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Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene.大鼠化学诱导性肝肿大的长期研究。I. 喂食苯巴比妥或丁基羟基甲苯时微粒体酶的持续诱导及无肝损伤情况
Toxicology. 1977 Jun;7(3):289-306. doi: 10.1016/0300-483x(77)90049-x.
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Interaction of isosafrole in vivo with rat hepatic microsomal cytochrome P-450 following treatment with phenobarbitone or 20-methylcholanthrene.苯巴比妥或20-甲基胆蒽处理后异黄樟素在体内与大鼠肝微粒体细胞色素P-450的相互作用。
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A novel haemoprotein induced by isosafrole pretreatment in the rat.
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Nodular hyperplasia in the rat liver following prolonged feeding of Ponceau MX.长期喂食丽春红MX后大鼠肝脏的结节性增生。
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Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.异丙嗪和异黄樟素对大鼠肝脏微粒体单加氧酶活性的影响：与经典诱导剂苯巴比妥和β-萘黄酮的比较。
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Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats.
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Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes.
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Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole.肝微粒体细胞色素P-450d的氨基末端和羧基末端序列，一种来自用异黄樟素处理过的大鼠的独特血红蛋白。
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