Kaliman P O, Amiri A
Ukr Biokhim Zh. 1977 May-Jun;49(3):70-5.
Distribution of lactate dehydrogenase (LDH) isoenzymes and content of lactic and pyruvic acids were studied in the heart, kidneys and skeletal muscle of rats at the age of 1, 3, 12 and 24 months at normal state and after thyroxine administration. With age the activity of aerobic isoenzymes of LDH increases and that of hybrid anaerobic isoenzymes of LDH decreases in the heart and kidneys; in the skeletal muscle the activity of LDH5 increases and that of LDH3 and LDH4 decreases, the content of the studied acids in the heart, kidneys and skeletal muscle changes irregularly. Under the effect of thyroxine the activity of aerobic isoenzymes of LDH increases in the heart of one-month animals and in the kidneys of one- and three-month animals, as well as in the skeletal muscle of 24-month rats; the activity of LDH5 rises in the skeletal muscle of one- and three-month animals. Thyroxine causes an increase in the content of pyruvic acid in the tissues of all the studied rats.
研究了1、3、12和24月龄正常状态及给予甲状腺素后的大鼠心脏、肾脏和骨骼肌中乳酸脱氢酶（LDH）同工酶的分布以及乳酸和丙酮酸的含量。随着年龄增长，心脏和肾脏中LDH的有氧同工酶活性增加，而LDH的混合厌氧同工酶活性降低；骨骼肌中LDH5活性增加，LDH3和LDH4活性降低，心脏、肾脏和骨骼肌中所研究酸的含量变化不规则。在甲状腺素作用下，1月龄动物心脏、1和3月龄动物肾脏以及24月龄大鼠骨骼肌中LDH的有氧同工酶活性增加；1和3月龄动物骨骼肌中LDH5活性升高。甲状腺素使所有研究大鼠组织中的丙酮酸含量增加。
