Vega G L, Grundy S M
Department of Clinical Nutrition, University of Texas, Southwestern Medical Center, Dallas 75235, USA.
Curr Opin Lipidol. 1996 Aug;7(4):209-16. doi: 10.1097/00041433-199608000-00007.
Low HDL levels are inversely related to risk for coronary heart disease. Several different mechanisms may account for this relationship. First, low HDL levels may be directly atherogenic; second, a low HDL often denotes high levels of other atherogenic lipoproteins (for example, remnants); and third, a low HDL frequently accompanies other coronary risk factors (for example, insulin resistance, diabetes, and raised blood pressure). This multiplicity of relationships probably explains the power of low HDL levels to predict acute coronary events.
高密度脂蛋白（HDL）水平低与冠心病风险呈负相关。几种不同的机制可能解释这种关系。首先，低HDL水平可能直接具有致动脉粥样硬化作用；其次，低HDL往往意味着其他致动脉粥样硬化脂蛋白（例如残粒）水平高；第三，低HDL常常伴有其他冠心病危险因素（例如胰岛素抵抗、糖尿病和血压升高）。这种多重关系可能解释了低HDL水平预测急性冠脉事件的能力。
