Scarmato V, Frank Y, Rozenstein A, Lu D, Hyman R, Bakshi S, Pahwa S, Pavlakis S
Department of Radiology, North Shore University Hospital, Cornell University Medical College, Manhasset, New York, USA.
AIDS. 1996 Sep;10(11):1227-31. doi: 10.1097/00002030-199609000-00008.
To determine differential patterns of brain atrophy in pediatric AIDS encephalopathy.
We measured the bicaudate, bifrontal, and ventricle-brain ratio in brain magnetic resonance imaging scans of 42 control children, nine children with progressive AIDS encephalopathy, 25 AIDS children without progressive encephalopathy, and 23 children with cerebral atrophy of other causes.
When compared with controls, encephalopathy patients showed significantly increased bicaudate and ventricle-brain ratios, but no significant increase in bifrontal ratio, whereas children with brain atrophy from causes other than AIDS showed increases in all three ratios.
Children with AIDS encephalopathy demonstrate a specific pattern of brain atrophy distinct from other etiologies: a central atrophy, primarily affecting the subcortical white matter or the basal ganglia regions.
确定小儿艾滋病脑病中脑萎缩的不同模式。
我们测量了42名对照儿童、9名患有进行性艾滋病脑病的儿童、25名无进行性脑病的艾滋病儿童以及23名其他原因导致脑萎缩的儿童的脑磁共振成像扫描中的双侧尾状核、双侧额叶和脑室-脑比率。
与对照组相比，脑病患者的双侧尾状核和脑室-脑比率显著增加，但双侧额叶比率无显著增加，而艾滋病以外原因导致脑萎缩的儿童所有三项比率均增加。
患有艾滋病脑病的儿童表现出一种与其他病因不同的特定脑萎缩模式：一种主要影响皮质下白质或基底神经节区域的中央萎缩。
