Gray F, Haug H, Chimelli L, Geny C, Gaston A, Scaravilli F, Budka H
Département Universitaire de Neurosciences Médicales, Faculté de Médecine de Créteil, Université Paris-Val de Marne, France.
Acta Neuropathol. 1991;82(3):229-33. doi: 10.1007/BF00294450.
A 25-year-old homosexual AIDS patient presented with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy. CT scans demonstrated progressive diffuse brain atrophy. Neuropathology showed predominant cortical changes including severe neuronal loss corroborated by morphometry. Only minimal changes were found in the white matter and basal ganglia. Immunocytochemistry for HIV stained occasional microglial cells more markedly in the cerebral cortex. This suggests that HIV infection of the brain may cause predominant cortical nerve cell loss, and that HIV encephalopathy is not necessarily due to white matter lesions.
一名25岁的同性恋艾滋病患者出现了与HIV脑病相符的进行性认知、运动和行为障碍。CT扫描显示进行性弥漫性脑萎缩。神经病理学显示主要为皮质改变，包括形态计量学证实的严重神经元丧失。在白质和基底神经节中仅发现轻微改变。HIV免疫细胞化学染色显示，大脑皮质中偶尔有小胶质细胞染色更明显。这表明脑部的HIV感染可能导致主要的皮质神经细胞丧失，且HIV脑病不一定是由白质病变引起的。
