Cicchetti F, Gould P V, Parent A
Centre de recherche en Neurobiologie, Hôpital de I'Enfant, Jésus, Québec, Canada.
Brain Res. 1996 Aug 19;730(1-2):232-7. doi: 10.1016/0006-8993(96)00307-1.
Immunohistochemical studies of the striatum in normal human subjects with a double-antigen localization method have revealed the presence of large and medium-sized aspiny neurons displaying immunoreactivity for both the calcium-binding protein calretinin and substance P (neurokinin-1) receptor. These large and medium-sized cells from two distinct classes of striatal interneurons, which together represent less than 3% of the total neuronal population of the human striatum. Observations made in four cases of Huntington's disease revealed that such doubly labeled interneurons are still present in the striatum of these patients, despite the marked atrophy of the structure. This study provides the first evidence for the existence of interneurons containing calretinin and expressing tachykinin receptors in the human striatum. It also demonstrates the selective sparing of these chemospecific striatal neurons in Huntington's disease.
采用双抗原定位法对正常人类受试者纹状体进行的免疫组织化学研究显示，存在大型和中型无棘神经元，它们对钙结合蛋白钙视网膜蛋白和P物质（神经激肽-1）受体均显示免疫反应性。这些大型和中型细胞来自两类不同的纹状体中间神经元，它们合起来占人类纹状体神经元总数的不到3%。对4例亨廷顿病患者的观察发现，尽管结构明显萎缩，但这些双标记中间神经元仍存在于这些患者的纹状体中。这项研究首次证明了人类纹状体中存在含有钙视网膜蛋白并表达速激肽受体的中间神经元。它还证明了这些化学特异性纹状体神经元在亨廷顿病中具有选择性保留。
