Yamada K, Goto S, Oyama T, Yoshikawa M, Nagahiro S, Ushio Y
Department of Neurosurgery, Kumamoto University Medical School, Japan.
Acta Neuropathol. 1995;89(2):172-7. doi: 10.1007/BF00296362.
The present study concerns the vulnerability of striatal interneurons immunopositive for the Ca(2+)-binding protein calretinin to ischemic neuronal injury. An immunohistochemical study was carried out on the striata of rats which had undergone transient middle cerebral artery occlusion. Two weeks after the ischemia, there was a marked reduction in the number of calretinin-positive neurons in the ipsilateral ischemic lesion, although the striatal interneurons positive for parvalbumin, which are a neuronal population distinct from the calretinin-immunoreactive cells in the striatum, were spared in the insulted areas. The present data indicate that the striatal calretinin-positive neurons are less resistant to transient ischemia, suggesting that there may exist vulnerability differences among the striatal interneurons in ischemia-induced neuronal injury.
本研究关注对钙结合蛋白钙视网膜蛋白呈免疫阳性的纹状体中间神经元对缺血性神经元损伤的易损性。对经历短暂大脑中动脉闭塞的大鼠纹状体进行了免疫组织化学研究。缺血两周后，同侧缺血性病变中钙视网膜蛋白阳性神经元的数量显著减少，尽管对小白蛋白呈阳性的纹状体中间神经元（它们是纹状体中与钙视网膜蛋白免疫反应性细胞不同的神经元群体）在受损伤区域未受影响。目前的数据表明，纹状体中钙视网膜蛋白阳性神经元对短暂性缺血的抵抗力较弱，这表明在缺血诱导的神经元损伤中，纹状体中间神经元之间可能存在易损性差异。
