Jacobson E D
Yale J Biol Med. 1977 May-Jun;50(3):301-6.
The major regulatory factors in the mesenteric circulation include general hemodynamic forces, the autonomic nervous system, circulating vasoactive substances, tissue metabolites and intrinsic characteristics of vascular smooth muscle. During mesenteric ischemic states smooth muscle spasm elevates resistance to blood flow and aggravates intestinal tissue hypoxia leading to mucosal necrosis. Close intraarterial infusion of potent vasodilator drugs holds the promise of reversing intestinal ischemia and preserving viability of the gut.
肠系膜循环中的主要调节因素包括一般血流动力学力量、自主神经系统、循环血管活性物质、组织代谢产物以及血管平滑肌的内在特性。在肠系膜缺血状态下，平滑肌痉挛会增加血流阻力并加重肠道组织缺氧，导致黏膜坏死。通过动脉内密切输注强效血管扩张药物有望逆转肠道缺血并维持肠道的活力。
