Williams R A, Wilson S E
Am J Gastroenterol. 1980 May;73(5):408-13.
Mesenteric ischemia follows a critical reduction in blood flow to the intestine. Absence of a practical diagnostic test results in delayed diagnosis and inability to evaluate changes in blood flow due to vasodilator therapy. We recorded the disappearance of radioxenon (133Xe) from ischemic bowel to quantitate the decreased perfusion and to assess changes in submucosal blood flow after intra-arterial papaverine. The ischemic colon, its only blood supply from collaterals, was formed into a Thirty-Vella loop. An infusion catheter placed at the origin of the superior mesenteric artery (SMA) was used to deliver saline or papaverine (0.1 mg./kg./min). Eleven control dogs received N.S. only. In nine dogs papaverine infusion was started immediately and in another 12 dogs two hours after the production of ischemia. Submucosal blood flow was determined by the per cent washout at two minutes of an 0.05 ml. injection of 133Xe dissolved in N.S., made into the submucosal space of the colostomy.
肠系膜缺血是由于肠道血流严重减少所致。缺乏实用的诊断测试导致诊断延迟，并且无法评估血管扩张剂治疗引起的血流变化。我们记录了放射性氙（133Xe）从缺血肠段的消失情况，以定量灌注减少情况，并评估动脉内注射罂粟碱后黏膜下血流的变化。缺血结肠仅通过侧支获得血液供应，将其做成一个Thirty-Vella袢。放置在上肠系膜动脉（SMA）起始处的输注导管用于输送生理盐水或罂粟碱（0.1毫克/千克/分钟）。11只对照犬仅接受生理盐水。9只犬立即开始输注罂粟碱，另外12只犬在产生缺血两小时后开始输注。通过向结肠造口术的黏膜下间隙注射0.05毫升溶解于生理盐水中的133Xe后两分钟的洗脱百分比来测定黏膜下血流。
