Basile-Borgia A, Abel J H
Department of Cardiovascular Perfusion, Easton Hospital, Pennsylvania 18042, USA.
Perfusion. 1996 Jul;11(4):338-45. doi: 10.1177/026765919601100407.
Most lipids are carried in the circulation by lipoproteins. Lipoproteins and their associated proteins, called apolipoproteins, are currently being studied in an effort to further our understanding of atherosclerotic cardiovascular disease. Lipoprotein assembly, secretion, transportation, modification and clearance are essential elements of healthy lipid metabolism. When one or more of these key steps becomes altered, various disease states are induced. Current data suggest that lipoprotein(a), a low density lipoprotein (LDL)-like particle, is an acute phase reactant that plays a critical role in the modulation of fibrinolysis. Several aspects of lipoproteins and lipoprotein metabolism will be examined. Emphasis will be placed on the proatherogenic and thrombogenic effects of oxidized LDL.
大多数脂质通过脂蛋白在循环系统中运输。脂蛋白及其相关蛋白（称为载脂蛋白）目前正在研究中，以加深我们对动脉粥样硬化性心血管疾病的理解。脂蛋白的组装、分泌、运输、修饰和清除是健康脂质代谢的关键要素。当这些关键步骤中的一个或多个发生改变时，就会引发各种疾病状态。目前的数据表明，脂蛋白(a)，一种类似低密度脂蛋白(LDL)的颗粒，是一种急性期反应物，在纤维蛋白溶解的调节中起关键作用。本文将探讨脂蛋白和脂蛋白代谢的几个方面。重点将放在氧化型低密度脂蛋白的促动脉粥样硬化和促血栓形成作用上。
